Diabetes Care
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Diabetes Care, Vol 10, Issue 5 555-557, Copyright © 1987 by American Diabetes Association

ARTICLES

Efficacy of glyburide in diabetics poorly controlled on first-generation oral hypoglycemics

KL Cohen and S Harris
Department of Medicine, Yale University School of Medicine, West Haven, Connecticut.

Twenty-four type II (non-insulin-dependent) diabetic patients poorly controlled on maximum doses of first-generation oral hypoglycemic agents were switched to glyburide. There was a significant decrease in glycosylated hemoglobin, but the level was normalized in only four patients; there was no correlation with age, weight, or duration of diabetes. The best predictor for improvement was initial failure on tolbutamide, as opposed to the other first-generation drugs. Patients not controlled with 500 mg/day of chlorpropamide were less likely to benefit from glyburide therapy.
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S. E. Inzucchi
Oral Antihyperglycemic Therapy for Type 2 Diabetes: Scientific Review
JAMA, January 16, 2002; 287(3): 360 - 372.
[Abstract] [Full Text] [PDF]


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Copyright © 1987 by the American Diabetes Association.