Diabetes Care, Vol 10, Issue 6 748-751, Copyright © 1987 by American Diabetes Association
Effect of pregnancy on autonomic nervous function and heart rate in diabetic and nondiabetic women
KE Airaksinen, PI Salmela, MJ Ikaheimo, P Kirkinen, MK Linnaluoto and JT Takkunen
Department of Medicine, Oulu University Central Hospital, Finland.
Supine and standing heart rate and heart rate responses to deep breathing
and standing up (the 30-to-15 ratio), indices of autonomic nervous
function, were measured during each trimester and postpartum in 25 women
with insulin-dependent diabetes and 10 nondiabetic women. The groups did
not differ with respect to autonomic function in the basal state
(postpartum), and the heart rate response to deep breathing diminished
progressively in both groups during pregnancy, although the change tended
to be less pronounced in the diabetic women. The 30-to-15 ratio did not
alter significantly during pregnancy. The diabetic women had a higher
supine heart rate than the healthy women in the basal state, but the
pregnancy-induced increase in heart rate was less in the diabetic women.
Thus, the reversible diminution of heart rate response to deep breathing
during pregnancy is a physiological finding and does not denote development
of autonomic nervous dysfunction. Second, the increase in heart rate, a
primary cardiovascular adjustment to pregnancy, seems to be blunted in
diabetic women.