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Diabetes Care, Vol 16, Issue 4 557-559, Copyright © 1993 by American Diabetes Association

ARTICLES

Effects of benfluorex on insulin resistance and lipid metabolism in obese type II diabetic patients

R Bianchi, V Bongers, B Bravenboer and DW Erkelens
Department of Internal Medicine, University Hospital, Utrecht, The Netherlands.

OBJECTIVE--To evaluate the change in lipids and insulin sensitivity in 10 obese type II diabetic patients after treatment with benfluorex or placebo for 2 wk. RESEARCH DESIGN AND METHODS--The study had a double-blind, cross-over design. Insulin sensitivity was measured with the euglycemic hyperinsulinemic glucose clamp technique at two different insulin infusion rates: 0.05 (clamp 1) and 0.10 U.kg-1.h-1 (clamp 2). RESULTS--Subanalysis of the glucose infusion rate under steady-state conditions in the last 30 min of clamp 2 yielded a glucose infusion rate of 5.36 and 3.87 mmol.kg-1.min-1 after benfluorex and placebo, respectively (P = 0.018). CONCLUSIONS--Benfluorex increases insulin sensitivity in obese type II diabetic patients.
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