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Diabetes Care, Vol 16, Issue 5 809-811, Copyright © 1993 by American Diabetes Association

ARTICLES

Low levels of intraplatelet cGMP in IDDM

JA Amado, E Salas, MA Botana, JJ Poveda and JR Berrazueta
Department of Medicine, Hospital Universitario Marques de Valdecilla, University of Cantabria, Spain.

OBJECTIVE--To determine the levels of intraplatelet cGMP, an index of activity of the antiaggregatory nitric oxide pathway, in IDDM patients. RESEARCH DESIGN AND METHODS--We measured intraplatelet and plasmatic cGMP levels in 22 IDDM patients and 22 age- and sex-matched control subjects. RESULTS--Intraplatelet cGMP levels decreased in the IDDM patients (0.32 +/- 0.16 pmol/10(9) platelets) when compared with the control group (0.52 +/- 0.32 pmol/10(9) platelets), P = 0.032. Plasmatic cGMP levels were not significantly different between groups. Intraplatelet cGMP levels correlated negatively with the duration of the disease (r = -0.43, P < 0.05). CONCLUSIONS--IDDM patients have lower levels of intraplatelet cGMP, which may be responsible in part for their platelet hyperactivity.
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A. I. Vinik, T. Erbas, T. S. Park, R. Nolan, and G. L. Pittenger
Platelet Dysfunction in Type 2 Diabetes
Diabetes Care, August 1, 2001; 24(8): 1476 - 1485.
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Copyright © 1993 by the American Diabetes Association.