Diabetes Care, Vol 16, Issue 9 1276-1284, Copyright © 1993 by American Diabetes Association

ARTICLES

Clinical gallbladder disease in NIDDM subjects. Relationship to duration of diabetes and severity of glycemia

SM Haffner, AK Diehl, R Valdez, BD Mitchell, HP Hazuda, P Morales and MP Stern
Department of Medicine, University of Texas Health Science Center, San Antonio 78284.

OBJECTIVE--To examine the relationship between the prevalence of gallbladder disease and severity of glycemia among diabetic individuals and to provide insight into whether the diabetes-gallstone association is a causal one, because NIDDM patients have an increased prevalence of clinical gallbladder disease. RESEARCH DESIGN AND METHODS--We examined 462 diabetic individuals identified during the San Antonio Heart Study, a population-based survey of diabetes and cardiovascular disease in Mexican Americans and non-Hispanic whites. Diabetes was diagnosed according to National Diabetes Data Group criteria. RESULTS--The prevalence of self-reported gallbladder disease was 34.2% in diabetic women and 7.2% in diabetic men. Although duration of diabetes was positively related to the prevalence of gallbladder disease (P < 0.01), type of therapy was not associated, and fasting glucose concentration was inversely associated with gallbladder disease. CONCLUSIONS--Factors other than hyperglycemia may account for the increased prevalence of gallbladder disease in diabetic subjects.
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