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Diabetes Care, Vol 18, Issue 2 241-244, Copyright © 1995 by American Diabetes Association

ARTICLES

Prospective study of lipoprotein(a) as a risk factor for atherosclerotic cardiovascular disease in patients with diabetes

T Hiraga, T Kobayashi, M Okubo, K Nakanishi, T Sugimoto, Y Ohashi and T Murase
Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan.

OBJECTIVE--To assess whether lipoprotein(a) [Lp(a)] is a risk factor for atherosclerotic cardiovascular disease in diabetes. RESEARCH DESIGN AND METHODS--We studied 221 patients with non-insulin-dependent diabetes mellitus (NIDDM) without diabetic complications who were followed for 2.2-3.1 years. Their serum Lp(a) levels were semiquantified by a rapid electrophoretic method that accurately discriminates high from low serum Lp(a) at the 20 mg/dl level. RESULTS--Seven of 105 diabetic patients with a high serum Lp(a) experienced a clinical event related to atherosclerotic cardiovascular disease. This incidence was significantly higher than that of the 110 diabetic patients with a low serum Lp(a). The logistic regression analysis revealed that Lp(a) was an independent risk factor for the event. CONCLUSIONS--Lp(a) is a significant risk factor for atherosclerotic cardiovascular disease in NIDDM.
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Copyright © 1995 by the American Diabetes Association.