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Diabetes Care, Vol 18, Issue 5 677-680, Copyright © 1995 by American Diabetes Association

ARTICLES

HLA-DQ beta 1 typing and non-Asp57 alleles in the aborigine population of Senegal

M Chauffert, A Cisse, D Chevenne, B Parfait, S Michel and F Trivin
Laboratoire de Biochimie, Foundation Hopital Saint-Joseph, Paris, France.

OBJECTIVE--To investigate, in Senegalese subjects, the frequency of human leukocyte antigen (HLA)-DQ beta 1 alleles and their role in susceptibility to insulin-dependent diabetes mellitus (IDDM). RESEARCH DESIGN AND METHODS--HLA-DQ beta 1 typing was done in 55 IDDM subjects and 118 nondiabetic control subjects by means of polymerase chain reaction restriction fragment length polymorphism. RESULTS--Alleles bearing a codon for an Asp residue at position 57 in the DQ beta-chain were associated with a significantly lower risk of IDDM. Alleles 0201 and 0302 (Ala57) were positively associated with diabetes, but allele 0501 (Val57) was less frequent in IDDM subjects than in control subjects. CONCLUSIONS--HLA-DQ beta 1 alleles may be genetic susceptibility markers for IDDM in the Senegalese population, as they are in Caucasian populations.
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Copyright © 1995 by the American Diabetes Association.