Diabetes Care
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Barrett-Connor, E.
Right arrow Articles by Kritz-Silverstein, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Barrett-Connor, E.
Right arrow Articles by Kritz-Silverstein, D.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes Care, Vol 19, Issue 12 1388-1392, Copyright © 1996 by American Diabetes Association

ARTICLES

Does hyperinsulinemia preserve bone?

E Barrett-Connor and D Kritz-Silverstein
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla 92093-0607, USA. ebarrettconnor@ucsd.edu

OBJECTIVE: Obesity and NIDDM are each associated with increased bone mineral density (BMD). We therefore hypothesize that hyperinsulinemia is an osteogenic factor. RESEARCH DESIGN AND METHODS: Subjects consisted of 411 men and 559 women aged 50-89 years who were participants in the Rancho Bernardo Heart and Chronic Disease Study and were not diabetic by history or oral glucose tolerance test. Fasting and 2-h postchallenge insulin were measured by radioimmunoassay. Bone mineral density was measured at the midshaft radius with single photon absorptiometry and at the lumbar spine and hip with dual energy X-ray absorptiometry. RESULTS: Multiple regression analyses indicated that among men, a significant insulin-BMD association at the hip was no longer apparent after adjusting for covariates. Among women, fasting insulin was significantly and positively associated with bone density of the radius and spine (P < 0.05), independent of age, BMI, waist-hip ratio, postmenopausal estrogen use, age at menopause, thiazide use, family history of diabetes, current cigarette smoking, and exercise. Each 10 microU/ml increase in fasting insulin was associated with an increase of 0.33 and 0.57 g/cm2 of the radius and spine, respectively. CONCLUSIONS: Hyperinsulinemia may be responsible for part of the observed association of both diabetes and obesity with BMD in women.
Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 EndocrinologyHome page
B. M. Abdallah, M. Ding, C. H. Jensen, N. Ditzel, A. Flyvbjerg, T. G. Jensen, F. Dagnaes-Hansen, J. A. Gasser, and M. Kassem
Dlk1/FA1 Is a Novel Endocrine Regulator of Bone and Fat Mass and Its Serum Level Is Modulated by Growth Hormone
Endocrinology, July 1, 2007; 148(7): 3111 - 3121.
[Abstract] [Full Text] [PDF]

Home page
 Dentomaxillofac RadiolHome page
S Ay, U. Gursoy, T Erselcan, and I Marakoglu
Assessment of mandibular bone mineral density in patients with type 2 diabetes mellitus
Dentomaxillofac. Radiol., November 1, 2005; 34(6): 327 - 331.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. M. Thrailkill, C. K. Lumpkin Jr., R. C. Bunn, S. F. Kemp, and J. L. Fowlkes
Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues
Am J Physiol Endocrinol Metab, November 1, 2005; 289(5): E735 - E745.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
K. M. Thrailkill, L. Liu, E. C. Wahl, R. C. Bunn, D. S. Perrien, G. E. Cockrell, R. A. Skinner, W. R. Hogue, A. A. Carver, J. L. Fowlkes, et al.
Bone Formation Is Impaired in a Model of Type 1 Diabetes
Diabetes, October 1, 2005; 54(10): 2875 - 2881.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. Abou Samra, N. H. Baba, N. Torbay, L. Dib, and G. E.-H. Fuleihan
High Plasma Leptin Is Not Associated with Higher Bone Mineral Density in Insulin-Resistant Premenopausal Obese Women
J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 2588 - 2594.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
D J Hadjidakis, A M Mylonakis, M E Sfakianakis, A E Raptis, and S A Raptis
Diabetes and premature menopause: is their co-existence detrimental to the skeleton?
Eur. J. Endocrinol., March 1, 2005; 152(3): 437 - 442.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
A. Afghani, M. L. Cruz, and M. I. Goran
Impaired Glucose Tolerance and Bone Mineral Content in Overweight Latino Children With a Family History of Type 2 Diabetes
Diabetes Care, February 1, 2005; 28(2): 372 - 378.
[Abstract] [Full Text] [PDF]

Home page
 Clin. DiabetesHome page
S. A. Brown and J. L. Sharpless
Osteoporosis: An Under-appreciated Complication of Diabetes
Clin. Diabetes, January 1, 2004; 22(1): 10 - 20.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. V. Zborowski, J. A. Cauley, E. O. Talbott, D. S. Guzick, and S. J. Winters
Bone Mineral Density, Androgens, and the Polycystic Ovary: The Complex and Controversial Issue of Androgenic Influence in Female Bone
J. Clin. Endocrinol. Metab., October 1, 2000; 85(10): 3496 - 3506.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 1996 by the American Diabetes Association.