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Diabetes Care, Vol 19, Issue 3 255-256, Copyright © 1996 by American Diabetes Association

ARTICLES

Human insulin-induced lipoatrophy. Successful treatment using a jet-injection device

S Logwin, I Conget, M Jansa, M Vidal, C Nicolau and R Gomis
Endocrinology Unit, Hospital Clinic, Barcelona, Spain.

OBJECTIVE: To evaluate the efficacy of the administration of insulin by a jet-injector device in stopping and reversing severe human insulin-induced lipoatrophy. CASE: We report a case of a woman with severe human insulin-induced lipoatrophy who has been treated exclusively with recombinant DNA human insulin since the onset of IDDM. RESULTS: The loss of subcutaneous tissue in the injection areas was demonstrated and measured by high-frequency ultrasound. Dermatologic exam demonstrated a severe reduction of fat tissue. After 8 months of administration of human insulin by a jet injector, there were no more new lesions of lipoatrophy and those affected areas were substantially ameliorated. CONCLUSIONS: Jet-injection devices might constitute a helpful method to treat those patients affected by severe human insulin-induced lipoatrophy.
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Copyright © 1996 by the American Diabetes Association.