Diabetes Care, Vol 19, Issue 8 822-826, Copyright © 1996 by American Diabetes Association
Effect of maternal diabetes on the pattern of selected insulin resistance syndrome parameters in normal glucose tolerant subjects of two Algonquin Indian communities in Quebec
JM Ekoe, F Thomas, B Balkau, E Eschwege and H Delisle
Department of Medicine, University of Montreal, Quebec, Canada.
OBJECTIVE: To determine whether a maternal antecedent with diabetes has an
effect on insulin resistance syndrome parameters. RESEARCH DESIGN AND
METHODS: We studied 352 Algonquin Indians from Quebec aged at least 15
years who had no personal antecedents with diabetes. Data concerned
clinical and biological parameters and the parental antecedents with
diabetes. RESULTS: For subjects over > 30 years, fasting insulin and
cholesterol levels were significantly higher in the group with a maternal
history of diabetes than in the group with a paternal history. Significant
differences were observed for serum triglyceride, BMI, and subscapular
skinfold thickness when comparing subjects with a maternal history and
those with no parental history of diabetes. Blood pressure and fasting
glucose did not differ according to parental history. CONCLUSIONS: Subjects
of maternal antecedents with diabetes have known risk factors for NIDDM.
This study does not identify whether there is a genetic or maternal
environmental reason for this association.