Diabetes Care, Vol 19, Issue 8 880-882, Copyright © 1996 by American Diabetes Association

ARTICLES

Hyperglycemia affects cardiovascular autonomic nerve function in normal subjects

BB Yeap, A Russo, RJ Fraser, GA Wittert and M Horowitz
Department of Medicine, Royal Adelaide Hospital, North Terrace, Adelaide, Australia.

OBJECTIVE: To evaluate the effect of acute hyperglycemia on autonomic nerve function in normal subjects. RESEARCH DESIGN AND METHODS: Six healthy volunteers ages 19-32 years underwent paired studies during euglycemia (blood glucose 5.1 +/- 0.04 mmol/l) and hyperglycemia (blood glucose 15.7 +/- 0.48 mmol/l) induced by intravenous infusion of glucose and maintained for 150 min. The order of the two studies was randomized. In each experiment, supine heart rate, heart rate variation with respiration, ratio of the maximum to minimum R-R interval after standing ("30:15" ratio), systolic blood pressure response to standing, and diastolic blood pressure response to sustained handgrip were measured. Data were analyzed using repeated measures analysis of variance. RESULTS: The supine heart rate was greater (P = 0.04) and the "30:15" ratio less (P = 0.03) during hyperglycemia than during euglycemia. Hyperglycemia had no significant effect on any of the other cardiovascular reflex tests. CONCLUSIONS: These observations indicate that acute hyperglycemia affects autonomic nerve function in healthy humans.
CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				A. Weissman, L. Lowenstein, A. Peleg, I. Thaler, and E. Z. Zimmer Power Spectral Analysis of Heart Rate Variability During the 100-g Oral Glucose Tolerance Test in Pregnant Women. Diabetes Care, March 1, 2006; 29(3): 571 - 574. [Abstract] [Full Text] [PDF]

				M. Petrova, R. Townsend, and K. L. Teff Prolonged (48-Hour) Modest Hyperinsulinemia Decreases Nocturnal Heart Rate Variability and Attenuates the Nocturnal Decrease in Blood Pressure in Lean, Normotensive Humans J. Clin. Endocrinol. Metab., March 1, 2006; 91(3): 851 - 859. [Abstract] [Full Text] [PDF]

				Q. Zhang, M. Horowitz, R. Rigda, C. Rayner, A. Worynski, and R. H. Holloway Effect of hyperglycemia on triggering of transient lower esophageal sphincter relaxations Am J Physiol Gastrointest Liver Physiol, May 1, 2004; 286(5): G797 - G803. [Abstract] [Full Text] [PDF]

				C. K. Rayner, M. Samsom, K. L. Jones, and M. Horowitz Relationships of Upper Gastrointestinal Motor and Sensory Function With Glycemic Control Diabetes Care, February 1, 2001; 24(2): 371 - 381. [Abstract] [Full Text]

				C. K. Rayner, H. S. Park, S. M. Doran, I. M. Chapman, and M. Horowitz Effects of cholecystokinin on appetite and pyloric motility during physiological hyperglycemia Am J Physiol Gastrointest Liver Physiol, January 1, 2000; 278(1): G98 - G104. [Abstract] [Full Text] [PDF]

				A Russo, W M Sun, Y Sattawatthamrong, R Fraser, M Horowitz, J M Andrews, and N W Read Acute hyperglycaemia affects anorectal motor and sensory function in normal subjects Gut, October 1, 1997; 41(4): 494 - 499. [Abstract] [Full Text] [PDF]