Diabetes Care
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Diabetes Care, Vol 2, Issue 2 209-214, Copyright © 1979 by American Diabetes Association

ARTICLES

Studies of the HLA system and insulin-dependent diabetes mellitus

M Christy, A Green, B Christau, H Kromann, J Nerup, P Platz, M Thomsen, LP Ryder and A Svejgaard

The relationship between the HLA system and insulin-dependent diabetes mellitus (IDDM) is reviewed. Data compiled by the HLA and Disease Registry reveal that HLA-B8 and/or Dw3 are associated with IDDM in all populations studied so far, but further population studies in non-Caucasian populations should be performed. In Caucasians, HLA-Dw2 renders protection against IDDM while HLA-Dw3 and Dw4 are associated with susceptibility to IDDM. The exact mode of inheritance of susceptibility to IDDM remains to be established. Involvement of at least two genes is likely. Heterogeneity of IDDM is highly possible and should be a matter of major interest in diabetes research.
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 Cold Spring Harb Symp Quant BiolHome page
M.L. Hoover, G. Angelini, E. Ball, P. Stastny, J. Marks, J. Rosenstock, P. Raskin, G.B. Ferrara, R. Tosi, and J.D. Capra
HLA-DQ and T-cell Receptor Genes in Insulin-dependent Diabetes Mellitus
Cold Spring Harb Symp Quant Biol, January 1, 1986; 51(0): 803 - 809.
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Copyright © 1979 by the American Diabetes Association.