Diabetes Care
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rissanen, J.
Right arrow Articles by Laakso, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rissanen, J.
Right arrow Articles by Laakso, M.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes Care, Vol 20, Issue 8 1319-1323, Copyright © 1997 by American Diabetes Association

ARTICLES

The Trp64Arg polymorphism of the beta 3-Adrenergic receptor gene. Lack of association with NIDDM and features of insulin resistance syndrome

J Rissanen, J Kuopusjarvi, J Pihlajamaki, R Sipilainen, S Heikkinen, M Vanhala, P Kekalainen, J Kuusisto and M Laakso
Department of Medicine, University of Kuopio, Finland.

OBJECTIVE: To investigate the association of the Trp64Arg polymorphism of the beta3-adrenergic receptor gene with NIDDM and the features of insulin resistance syndrome in subjects from eastern Finland. RESEARCH DESIGN AND METHODS: We determined the prevalence of the Trp64Arg polymorphism of the beta3-adrenergic receptor gene by restriction fragment length polymorphism analysis in 110 patients with NIDDM (54 men and 56 women, age 63 +/- 1 years, BMI 30.4 +/- 0.5 kg/m2), in 183 patients with features of insulin resistance syndrome (103 men and 80 women, age 44 +/- 0 years, BMI 31.1 +/- 0.4 kb/m2), and in 82 normoglycemic control men (age 54 +/- 1 years, BMI 26.3 +/- 0.4 kg/m2). RESULTS: The allele frequency of the Trp64Arg polymorphism of the beta3-adrenergic receptor gene was similar in patients with NIDDM, in patients with insulin resistance syndrome, and in control subjects (0.08, 0.07, and 0.07, respectively; NS). In addition, this polymorphism was not associated with low resting metabolic rate, abdominal obesity, increased lipid oxidation, hypertension, or earlier development of NIDDM as previously described. Furthermore, in 82 normoglycemic male control subjects the Trp64Arg polymorphism was not associated with insulin resistance evaluated by the euglycemic-hyperinsulinemic clamp. CONCLUSIONS: The Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is unlikely to be a major genetic predisposer to NIDDM or insulin resistance syndrome in subjects from eastern Finland.
Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Diabetes CareHome page
T. Oizumi, M. Daimon, T. Saitoh, W. Kameda, H. Yamaguchi, H. Ohnuma, M. Igarashi, H. Eguchi, H. Manaka, M. Tominaga, et al.
Genotype Arg/Arg, but not Trp/Arg, of the Trp64Arg Polymorphism of the {beta}3-Adrenergic Receptor Is Associated With Type 2 Diabetes and Obesity in a Large Japanese Sample
Diabetes Care, September 1, 2001; 24(9): 1579 - 1583.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
N. Shihara, K. Yasuda, T. Moritani, H. Ue, T. Adachi, H. Tanaka, K. Tsuda, and Y. Seino
The Association between Trp64Arg Polymorphism of the {beta}3-Adrenergic Receptor and Autonomic Nervous System Activity
J. Clin. Endocrinol. Metab., May 1, 1999; 84(5): 1623 - 1627.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Festa, W. Krugluger, N. Shnawa, P. Hopmeier, S. M. Haffner, and G. Schernthaner
Trp64Arg Polymorphism of the {beta}3-Adrenergic Receptor Gene in Pregnancy: Association with Mild Gestational Diabetes Mellitus
J. Clin. Endocrinol. Metab., May 1, 1999; 84(5): 1695 - 1699.
[Abstract] [Full Text]

Home page
 Physiol. Rev.Home page
E. Jequier and L. Tappy
Regulation of Body Weight in Humans
Physiol Rev, April 1, 1999; 79(2): 451 - 480.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Fogelholm, R. Valve, K. Kukkonen-Harjula, A. Nenonen, V. Hakkarainen, M. Laakso, and M. Uusitupa
Additive Effects of the Mutations in the {beta}3-Adrenergic Receptor and Uncoupling Protein-1 Genes on Weight Loss and Weight Maintenance in Finnish Women
J. Clin. Endocrinol. Metab., December 1, 1998; 83(12): 4246 - 4250.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. GarcÍa-Rubi, R. D. Starling, A. Tchernof, D. E. Matthews, J. D. Walston, A. R. Shuldiner, K. Silver, E. T. Poehlman, and J. Calles-Escandón
Trp64Arg Variant of the {beta}3-Adrenoceptor and Insulin Resistance in Obese Postmenopausal Women
J. Clin. Endocrinol. Metab., November 1, 1998; 83(11): 4002 - 4005.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. Fujisawa, H. Ikegami, Y. Kawaguchi, and T. Ogihara
Meta-Analysis of the Association of Trp64Arg Polymorphism of {beta}3-Adrenergic Receptor Gene with Body Mass Index
J. Clin. Endocrinol. Metab., July 1, 1998; 83(7): 2441 - 2444.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 1997 by the American Diabetes Association.