Diabetes Care
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kumar, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kumar, D.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes Care, Vol 20, Issue 9 1357-1359, Copyright © 1997 by American Diabetes Association

ARTICLES

Lispro analog for treatment of generalized allergy to human insulin

D Kumar
Department of Medicine, University of Southern California School of Medicine, Los Angeles County Medical Center, USA.

OBJECTIVE: To evaluate the clinical usefulness of the human insulin analog lispro in a patient with generalized allergy to human insulin. RESEARCH DESIGN AND METHODS: A 34-year-old obese female patient developed systemic allergic reactions to human insulin but tolerated insulin lispro. Sequential analyses of the anti-insulin IgE and IgG immunoglobulins were performed. RESULTS: On intradermal test, the lispro insulin produced a 50% less intense wheal-flare response, compared with human insulin, which was presumed to be due to lispro's molecular form. The intradermal reactivity to both human and lispro insulins decreased with time and disappeared by week 25. 125I-labeled lispro and human insulin binding antibody titers of both the IgE and IgG immunoglobulins were high initially, but decreased progressively, becoming very low by the end of 1 year. In in vitro immunoassay, the lispro and human insulins show a complete cross-reactivity. CONCLUSIONS: Lispro may be useful for the management of allergy to human insulin. This analog of human insulin appears to have a reduced immunogenic potency.
Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Diabetes CareHome page
A. Sola-Gazagnes, C. Pecquet, R. Radermecker, L. Pietri, F. Elgrably, G. Slama, and J.-L. Selam
Successful Treatment of Insulin Allergy in a Type 1 Diabetic Patient by Means of Constant Subcutaneous Pump Infusion of Insulin
Diabetes Care, October 1, 2003; 26(10): 2961 - 2962.
[Full Text] [PDF]

Home page
 Diabetes CareHome page
S. E. Fineberg, J. Huang, R. Brunelle, K. S. Gulliya, and J. H. Anderson Jr
Effect of Long-Term Exposure to Insulin Lispro on the Induction of Antibody Response in Patients With Type 1 or Type 2 Diabetes
Diabetes Care, January 1, 2003; 26(1): 89 - 96.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
L. Airaghi, M. Lorini, and A. Tedeschi
The Insulin Analog Aspart: A Safe Alternative in Insulin Allergy
Diabetes Care, November 1, 2001; 24(11): 2000 - 2000.
[Full Text] [PDF]

Home page
 Diabetes CareHome page
M. E. Griffin, A. Feder, and W. V. Tamborlane
Lipoatrophy Associated With Lispro Insulin in Insulin Pump Therapy: An old complication, a new cause?
Diabetes Care, January 1, 2001; 24(1): 174 - 174.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 1997 by the American Diabetes Association.