Diabetes Care, Vol 21, Issue 12 2129-2134, Copyright © 1998 by American Diabetes Association

ARTICLES

Hyperfiltration in African-American patients with type 2 diabetes. Cross-sectional and longitudinal data

RL Chaiken, M Eckert-Norton, M Bard, MA Banerji, J Palmisano, I Sachimechi and HE Lebovitz
Division of Endocrinology and Metabolism, State University of New York-Health Science Center at Brooklyn 11203, USA.

OBJECTIVE: Hyperfiltration may play a role in the development of diabetic nephropathy. African-American patients with diabetes have more than a fourfold increase in end-stage renal disease. The purpose of this study is to evaluate the impact of hyperfiltration on renal function in African-American patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: Renal function of 194 African-American patients with diagnosed type 2 diabetes from 1 month to 36 years was assessed by studies of isotopic glomerular filtration rate (GFR), serum creatinine, creatinine clearance, and 24-h urinary albumin excretion rates. Thirty-four patients with a duration of diagnosed type 2 diabetes from 1 month to 10 years were found to have hyperfiltration (GFR > or = 140 ml.min-1.1.73 m-2). Fifteen of these patients received longitudinal follow-up of renal function for as long as 15 years after the initial study. RESULTS: Hyperfiltration is present in 15 (36%) of 42 patients whose duration of diagnosed type 2 diabetes is < 1 year, and it persists for up to 10 years in 14-20% of patients with diagnosed type 2 diabetes. Patients with hyperfiltration are younger than their counterparts without hyperfiltration when matched for duration of diagnosed diabetes. When followed over time, those patients with hyperfiltration were not more likely to develop impaired renal function as measured by GFR or creatinine clearance. CONCLUSIONS: Hyperfiltration does not identify patients at risk for deterioration in renal function.
CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				R. M. Foutz, P. R. Grimm, and S. C. Sansom Insulin increases the activity of mesangial BK channels through MAPK signaling Am J Physiol Renal Physiol, June 1, 2008; 294(6): F1465 - F1472. [Abstract] [Full Text] [PDF]

				M. L. Caramori, P. Fioretto, and M. Mauer Enhancing the Predictive Value of Urinary Albumin for Diabetic Nephropathy J. Am. Soc. Nephrol., February 1, 2006; 17(2): 339 - 352. [Abstract] [Full Text] [PDF]

				M. Murussi, P. Baglio, J. L. Gross, and S. P. Silveiro Risk Factors for Microalbuminuria and Macroalbuminuria in Type 2 Diabetic Patients: A 9-year follow-up study Diabetes Care, June 1, 2002; 25(6): 1101 - 1103. [Full Text] [PDF]