Diabetes Care, Vol 21, Issue 2 271-277, Copyright © 1998 by American Diabetes Association

ARTICLES

Preserved endothelial function in IDDM patients, but not in NIDDM patients, compared with healthy subjects

MD Enderle, N Benda, RM Schmuelling, HU Haering and M Pfohl
Department IV of Internal Medicine, University of Tubingen, Germany.

OBJECTIVE: To examine endothelial function (EF) noninvasively in IDDM and NIDDM patients with long diabetes duration. RESEARCH DESIGN AND METHODS: We studied EF in 17 IDDM patients without diabetic complications and in 25 NIDDM patients with comparable glycemic control and with diabetic complications and compared both with nondiabetic control subjects matched for age, sex, and lumen diameter. Using high-resolution ultrasound, we measured the endothelial-dependent (FAD%) and independent vasodilation (GTN%); the blood flow at rest, postocclusive, and after application of 400 micrograms glyceroltrinitrate of the branchial artery; and the intima media thickness (IMT) of the common carotid artery. RESULTS: In the IDDM patients, neither FAD% (8.2 +/- 4.6 vs. 7.6 +/- 4.2%), GTN% (16.3 +/- 4.9 vs. 18.4 +/- 6.4%), nor postocclusive blood flow (40.6 +/- 19.1 vs. 39.3 +/- 23.6 cm/s) differed from the control subjects. IMT (0.59 +/- 0.10 vs. 0.55 +/- 0.14 mm) was slightly, but not significantly, elevated. In contrast, the NIDDM patients showed an impaired FAD% (3.8 +/- 3.3 vs. 6.9 +/- 4.4%, P < 0.01), no difference in GTN%, and a decreased postocclusive blood flow (18.5 +/- 13.8 vs. 32.7 +/- 20.0 cm/s, P < 0.01). IMT was significantly increased in NIDDM patients (0.77 +/- 0.14 vs. 0.62 +/- 0.10 mm, P < 0.001). CONCLUSIONS: In contrast to NIDDM patients with cardiovascular complications, IDDM patients with long diabetes duration and good long-term metabolic control do not have impaired EF compared with control subjects.
CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				E. Gkaliagkousi, J. Ritter, and A. Ferro Platelet-Derived Nitric Oxide Signaling and Regulation Circ. Res., September 28, 2007; 101(7): 654 - 662. [Abstract] [Full Text] [PDF]

				R.-E. W. Kavey, V. Allada, S. R. Daniels, L. L. Hayman, B. W. McCrindle, J. W. Newburger, R. S. Parekh, and J. Steinberger Cardiovascular Risk Reduction in High-Risk Pediatric Patients: A Scientific Statement From the American Heart Association Expert Panel on Population and Prevention Science; the Councils on Cardiovascular Disease in the Young, Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism, High Blood Pressure Research, Cardiovascular Nursing, and the Kidney in Heart Disease; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research: Endorsed by the American Academy of Pediatrics Circulation, December 12, 2006; 114(24): 2710 - 2738. [Abstract] [Full Text] [PDF]

				R. Lautamaki, K.E. J. Airaksinen, M. Seppanen, J. Toikka, R. Harkonen, M. Luotolahti, R. Borra, J. Sundell, J. Knuuti, and P. Nuutila Insulin Improves Myocardial Blood Flow in Patients With Type 2 Diabetes and Coronary Artery Disease Diabetes, February 1, 2006; 55(2): 511 - 516. [Abstract] [Full Text] [PDF]

				E. Cosson, I. Pham, P. Valensi, J. Paries, J.-R. Attali, and A. Nitenberg Impaired Coronary Endothelium-Dependent Vasodilation Is Associated With Microalbuminuria in Patients With Type 2 Diabetes and Angiographically Normal Coronary Arteries Diabetes Care, January 1, 2006; 29(1): 107 - 112. [Abstract] [Full Text] [PDF]

				M. R. Skilton, N. T. Lai, K. A. Griffiths, L. M. Molyneaux, D. K. Yue, D. R. Sullivan, and D. S. Celermajer Meal-related increases in vascular reactivity are impaired in older and diabetic adults: insights into roles of aging and insulin in vascular flow Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1404 - H1410. [Abstract] [Full Text] [PDF]

				S Jadhav, J Petrie, W Ferrell, S Cobbe, and N Sattar Insulin resistance as a contributor to myocardial ischaemia independent of obstructive coronary atheroma: a role for insulin sensitisation? Heart, December 1, 2004; 90(12): 1379 - 1383. [Abstract] [Full Text] [PDF]

				A. Natali, S. Baldeweg, E. Toschi, B. Capaldo, D. Barbaro, A. Gastaldelli, J. S. Yudkin, and E. Ferrannini Vascular Effects of Improving Metabolic Control With Metformin or Rosiglitazone in Type 2 Diabetes Diabetes Care, June 1, 2004; 27(6): 1349 - 1357. [Abstract] [Full Text] [PDF]

				F. De Cobelli, P. Fiorina, G. Perseghin, M. Magnone, M. Venturini, G. Zerbini, A. Zanello, G. Mazzolari, L. Monti, V. Di Carlo, et al. L-Arginine-Induced Vasodilation of the Renal Vasculature Is Preserved in Uremic Type 1 Diabetic Patients After Kidney and Pancreas but not After Kidney-Alone Transplantation Diabetes Care, April 1, 2004; 27(4): 947 - 954. [Abstract] [Full Text] [PDF]

				P. Fiorina, F. Folli, F. Bertuzzi, P. Maffi, G. Finzi, M. Venturini, C. Socci, A. Davalli, E. Orsenigo, L. Monti, et al. Long-Term Beneficial Effect of Islet Transplantation on Diabetic Macro-/Microangiopathy in Type 1 Diabetic Kidney-Transplanted Patients Diabetes Care, April 1, 2003; 26(4): 1129 - 1136. [Abstract] [Full Text] [PDF]

				K. K. Koh, M. H. Kang, D. K. Jin, S.-K. Lee, J. Y. Ahn, H. Y. Hwang, S. H. Yang, D. S. Kim, T. H. Ahn, and E. K. Shin Vascular effects of estrogen in type II diabetic postmenopausal women J. Am. Coll. Cardiol., November 1, 2001; 38(5): 1409 - 1415. [Abstract] [Full Text] [PDF]

				A. M Storey, C. J Perry, and J. R Petrie Review: Endothelial dysfunction in type 2 diabetes The British Journal of Diabetes & Vascular Disease, August 1, 2001; 1(1): 22 - 27. [Abstract] [PDF]

				O. Wendler, P. Landwehr, D. Bandner-Risch, T. Georg, and H.-J. Schafers Vasoreactivity of arterial grafts in the patient with diabetes mellitus: investigations on internal thoracic artery and radial artery conduits Eur. J. Cardiothorac. Surg., August 1, 2001; 20(2): 305 - 311. [Abstract] [Full Text] [PDF]

				P. Fiorina, E. La Rocca, M. Venturini, F. Minicucci, I. Fermo, R. Paroni, A. D’Angelo, M. Sblendido, V. Di Carlo, M. Cristallo, et al. Effects of Kidney-Pancreas Transplantation on Atherosclerotic Risk Factors and Endothelial Function in Patients With Uremia and Type 1 Diabetes Diabetes, March 1, 2001; 50(3): 496 - 501. [Abstract] [Full Text]

				D. Perregaux, A. Chaudhuri, S. Rao, A. Airen, M. Wilson, B.-H. Sung, and P. Dandona Brachial Vascular Reactivity in Blacks Hypertension, November 1, 2000; 36(5): 866 - 871. [Abstract] [Full Text] [PDF]

				B. M. Balletshofer, K. Rittig, M. D. Enderle, A. Volk, E. Maerker, S. Jacob, S. Matthaei, K. Rett, and H. U. Haring Endothelial Dysfunction Is Detectable in Young Normotensive First-Degree Relatives of Subjects With Type 2 Diabetes in Association With Insulin Resistance Circulation, April 18, 2000; 101(15): 1780 - 1784. [Abstract] [Full Text] [PDF]

				M. Ryan, D. McInerney, D. Owens, P. Collins, A. Johnson, and G.H. Tomkin Diabetes and the Mediterranean diet: a beneficial effect of oleic acid on insulin sensitivity, adipocyte glucose transport and endothelium-dependent vasoreactivity QJM, February 1, 2000; 93(2): 85 - 91. [Abstract] [Full Text] [PDF]

				W. Bagg, G.D. Braatvedt, and N. Sharpe A complex relationship: glucose, insulin and coronary artery disease Eur. Heart J., January 1, 2000; 21(1): 8 - 9. [PDF]

				T. Kawagishi, M. Matsuyoshi, M. Emoto, H. Taniwaki, H. Kanda, Y. Okuno, M. Inaba, E. Ishimura, Y. Nishizawa, and H. Morii Impaired Endothelium-Dependent Vascular Responses of Retinal and Intrarenal Arteries in Patients With Type 2 Diabetes Arterioscler. Thromb. Vasc. Biol., October 1, 1999; 19(10): 2509 - 2516. [Abstract] [Full Text] [PDF]

				M. Wei, E. S. Freedland, J. Q. Purnell, and J. D. Brunzell Excessive Weight Gain and Effects on Lipids With Intensive Therapy of Type 1 Diabetes JAMA, December 16, 1998; 280(23): 1991 - 19921. [Full Text] [PDF]

				M-D Enderle, S Schroeder, R Ossen, C Meisner, A Baumbach, H U Haering, K R Karsch, and M Pfohl Comparison of peripheral endothelial dysfunction and intimal media thickness in patients with suspected coronary artery disease Heart, October 1, 1998; 80(4): 349 - 354. [Abstract] [Full Text]