Diabetes Care, Vol 21, Issue 3 398-402, Copyright © 1998 by American Diabetes Association

ARTICLES

Cognitive function in an elderly population with persistent impaired glucose tolerance

M Vanhanen, K Koivisto, J Kuusisto, L Mykkanen, EL Helkala, T Hanninen, P Riekkinen, H Soininen and M Laakso
Department of Neurology, Kuopio University Hospital, Finland. matti.vanhanen@uku.fi

OBJECTIVE: To study cognitive function in an elderly population with persistent impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS: Fasting and postload 2-h plasma glucose and insulin levels were determined at baseline in a population-based sample of 1,300 people and repeated an average of 3.5 years later in 980 subjects. At follow-up, cognitive function was evaluated in subjects with persistent normal glucose tolerance (NGT; n = 506) and IGT (n = 80) with a brief neuropsychological test battery. RESULTS: Subjects with persistent IGT scored lower in the Mini-Mental State Examination (MMSE) and in the Buschke Selective Reminding Test long-term memory scores. Multiple linear regression analysis revealed that age, education, and insulin levels (either fasting or 2-h value) were associated with the MMSE score in subjects with persistent IGT. Other potential risk factors for impaired cognitive function were not significantly associated with the MMSE score. CONCLUSIONS: Our study showed that persistent IGT in the elderly is associated with mildly impaired cognitive function, and hyperinsulinemia may account for this association.
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