Diabetes Care
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Frost, D.
Right arrow Articles by Beischer, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Frost, D.
Right arrow Articles by Beischer, W.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes Care, Vol 21, Issue 5 836-840, Copyright © 1998 by American Diabetes Association

ARTICLES

Evaluation of the insertion/deletion ACE gene polymorphism as a risk factor for carotid artery intima-media thickening and hypertension in young type 1 diabetic patients

D Frost, M Pfohl, P Clemens, HU Haring and W Beischer
Third Department of Medicine, Burgerhospital Stuttgart, Germany.

OBJECTIVE: To study the distribution of the insertion/deletion polymorphism of the ACE gene in young type 1 diabetic patients and to evaluate possible associations between the ACE genotype, arterial hypertension, and intima-media thickness (IMT) of the common carotid artery. RESEARCH DESIGN AND METHODS: Study participants were 148 type 1 diabetic patients (56 men and 92 women), aged 14-44 years, with a diabetes duration of > or = 2 years. HbA1c, albuminuria, and lipid status were assessed by standard laboratory techniques; the ACE genotypes were assessed by polymerase chain reaction. The patients were categorized according to the presence or absence of hypertension, nephropathy, and retinopathy. The IMT, which can be used to estimate early stages of atherosclerosis, was measured by high-resolution ultrasonography. RESULTS: The ACE genotypes were distributed as follows: 21% II, 37% ID, 42% DD. The IMT values did not differ among patients with various ACE genotypes (0.63 +/- 0.15 mm), but the prevalence of hypertension was significantly higher in patients with DD (odds ratio, 4.26 versus II + ID; 95% CI, 1.64-11.06). Multiple linear regression analysis showed that only age, hypertension, and sex were determinants for the IMT. CONCLUSIONS: Our results suggest a relationship between the prevalence of hypertension and the deletion polymorphism of the ACE gene in young type 1 diabetic patients, but we could not find an association between carotid artery IMT and ACE genotype in this population.
Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Journal of Renin-Angiotensin-Aldosterone SystemHome page
B. Ozben, I. Altun, V. Sabri Hancer, A. K. Bilge, A. M. Tanrikulu, R. Diz-Kucukkaya, A. S. Fak, E. Yilmaz, and K. Adalet
Angiotensin-converting enzyme gene polymorphism in arrhythmogenic right ventricular dysplasia: is DD genotype helpful in predicting syncope risk?
Journal of Renin-Angiotensin-Aldosterone System, December 1, 2008; 9(4): 215 - 220.
[Abstract] [PDF]

Home page
 ANGIOLOGYHome page
A. Bilici, M. S. Ulgen, H. Nazaroglu, O. Ozturk, F. Ekici, C. Akgul, and B. Alan
The Effect of ACE Gene Polymorphisms on Doppler Blood Flow Parameters of Carotid and Brachial Arteries in Patients With Myocardial Infarction
Angiology, January 1, 2007; 57(6): 681 - 685.
[Abstract] [PDF]

Home page
 Diabetes CareHome page
Y. Yamasaki, N. Katakami, K. Sakamoto, H. Kaneto, M. Matsuhisa, H. Sato, M. Hori, M. Haneda, A. Kashiwagi, Y. Tanaka, et al.
Combination of multiple genetic risk factors is synergistically associated with carotid atherosclerosis in Japanese subjects with type 2 diabetes.
Diabetes Care, November 1, 2006; 29(11): 2445 - 2451.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
Y. Wang, M. C.Y. Ng, W. Y. So, P. C.Y. Tong, R. C.W. Ma, C. C. Chow, C. S. Cockram, and J. C.N. Chan
Prognostic Effect of Insertion/Deletion Polymorphism of the ACE Gene on Renal and Cardiovascular Clinical Outcomes in Chinese Patients With Type 2 Diabetes
Diabetes Care, February 1, 2005; 28(2): 348 - 354.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
T. A. Manolio, E. Boerwinkle, C. J. O'Donnell, and A. F. Wilson
Genetics of Ultrasonographic Carotid Atherosclerosis
Arterioscler. Thromb. Vasc. Biol., September 1, 2004; 24(9): 1567 - 1577.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
F. A. Sayed-Tabatabaei, J. J. Houwing-Duistermaat, C. M. van Duijn, and J. C.M. Witteman
Angiotensin-Converting Enzyme Gene Polymorphism and Carotid Artery Wall Thickness: A Meta-Analysis
Stroke, July 1, 2003; 34(7): 1634 - 1639.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
A. Losito, K. Kalidas, S. Santoni, L. Ceccarelli, and S. Jeffery
Polymorphism of renin-angiotensin system genes in dialysis patients--association with cerebrovascular disease
Nephrol. Dial. Transplant., December 1, 2002; 17(12): 2184 - 2188.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 1998 by the American Diabetes Association.