Diabetes Care, Vol 21, Issue 7 1086-1089, Copyright © 1998 by American Diabetes Association

ARTICLES

Asp905Tyr polymorphism of the gene for the skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in NIDDM

GQ Shen, H Ikegami, Y Kawaguchi, T Fujisawa, Y Hamada, H Ueda, M Shintani, K Nojima, Y Kawabata, K Yamada, N Babaya and T Ogihara
Department of Geriatric Medicine, Osaka University Medical School, Japan.

OBJECTIVE: To clarify the contribution of the Asp905Tyr polymorphism of the muscle-specific glycogen-targeting subunit of protein phosphatase 1 (PP1G) to insulin resistance and related diseases. RESEARCH DESIGN AND METHODS: We investigated the Asp905Tyr polymorphism of the PPP1R3 gene, which encodes the muscle-specific glycogen-targeting subunit of PP1G, in 259 Japanese patients with NIDDM and 194 healthy control subjects. RESULTS: No significant difference was found in the genotype distribution between NIDDM patients (N = 259; Asp/Asp = 0.10, Asp/Tyr = 0.44, Tyr/Try = 0.46) and healthy control subjects (n = 194; Asp/Asp = 0.13, Asp/Tyr = 0.37, Tyr/Tyr = 0.50) or between patient groups subdivided by the mode of treatment: NIDDM patients with insulin therapy (Asp/Asp = 0.14, Asp/Tyr = 0.46, Tyr/Tyr = 0.40) and those without insulin therapy (Asp/Asp = 0.07, Asp/Tyr = 0.43, Tyr/Tyr = 0.50). However, NIDDM patients with the Tyr allele, which was previously reported to be associated with insulin resistance, tended to have lower BMIs than those without this allele (Asp/Asp: 24.5 +/- 1.1 kg/m2, Asp/Tyr: 22.6 +/- 0.4 kg/m2, Tyr/Tyr: 22.8 + 0.3 kg/m2, P = 0.06 by analysis of variance). CONCLUSIONS: These data suggest that the Asp905Tyr polymorphism of the PPP1R3 gene is not associated with NIDDM or high BMI, both of which are known to be insulin-resistant states, in the Japanese population.
CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				C. Bouche, S. Serdy, C. R. Kahn, and A. B. Goldfine The Cellular Fate of Glucose and Its Relevance in Type 2 Diabetes Endocr. Rev., October 1, 2004; 25(5): 807 - 830. [Abstract] [Full Text] [PDF]

				M. Delibegovic, C. G. Armstrong, L. Dobbie, P. W. Watt, A. J.H. Smith, and P. T.W. Cohen Disruption of the Striated Muscle Glycogen Targeting Subunit PPP1R3A of Protein Phosphatase 1 Leads to Increased Weight Gain, Fat Deposition, and Development of Insulin Resistance Diabetes, March 1, 2003; 52(3): 596 - 604. [Abstract] [Full Text] [PDF]

				D Liolitsa, J Powell, and S Lovestone Genetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease J. Neurol. Neurosurg. Psychiatry, September 1, 2002; 73(3): 261 - 266. [Abstract] [Full Text] [PDF]

				S. Shenolikar and D. L. Brautigan Meeting Report: Targeting Protein Phosphatases-Medicines for the New Millenium Sci. Signal., November 7, 2000; 2000 (57): pe1 - pe1. [Abstract] [Full Text] [PDF]

				L. Ragolia, N. Duddy, and N. Begum Effect of an Asp905Tyr Mutation of the Glycogen-Associated Regulatory Subunit of Protein Phosphatase-1 on the Regulation of Glycogen Synthesis by Insulin and Cyclic Adenosine 3',5'-Monophosphate Agonists Mol. Endocrinol., October 1, 1999; 13(10): 1773 - 1783. [Abstract] [Full Text]