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Diabetes Care 29:521-525, 2006
DOI: 10.2337/diacare.29.03.06.dc05-1453
© 2006 by the American Diabetes Association
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Clinical Care/Education/Nutrition
Original Article

Chromium Treatment Has No Effect in Patients With Poorly Controlled, Insulin-Treated Type 2 Diabetes in an Obese Western Population

A randomized, double-blind, placebo-controlled trial

Nanne Kleefstra, MD1, Sebastiaan T. Houweling, MD, PHD1,2, Frank G.A. Jansman, PHARMD, PHD3,4, Klaas H. Groenier, PHD2, Rijk O.B. Gans, MD, PHD5, Betty Meyboom-de Jong, MD, PHD2, Stephan J.L. Bakker, MD, PHD5 and Henk J.G. Bilo, MD, PHD, FRCP1

1 Department of Internal Medicine, Isala Clinics, Weezenlanden Location, Zwolle, the Netherlands
2 Department of General Practice, University of Groningen, Groningen, the Netherlands
3 Department of Pharmacology and Pharmaceutical Care, Groningen University Institute for Drug Exploration, Groningen, the Netherlands
4 Department of Clinical Pharmacy, Isala Clinics, Weezenlanden Location, Zwolle, the Netherlands
5 Department of Internal Medicine, University Hospital Groningen, Groningen, the Netherlands

Address correspondence and reprint requests to Nanne Kleefstra, MD, Department of Internal Medicine, Isala Clinics, Weezenlanden Location, P.O. Box 10500, 8000 GM Zwolle, Netherlands. E-mail: kleefstra{at}langerhans.com

OBJECTIVE—Chromium treatment has been reported to improve glycemic control and insulin sensitivity in specific populations of patients with type 2 diabetes. The aim of this study was to determine the effect of chromium treatment on glycemic control in a Western population of insulin-dependent patients with type 2 diabetes.

RESEARCH DESIGN AND METHODS—In this 6-month double-blind study, patients with an HbA1c (A1C) >8% and insulin requirements of >50 units/day were randomly assigned to receive treatment with placebo or 500 or 1,000 µg chromium daily in the form of chromium picolinate. The primary efficacy parameter was a change in A1C. Secondary end points were changes in lipid profile, BMI, blood pressure, and insulin requirements.

RESULTS—In this per-protocol analysis (n = 46), the decrease in A1C was approximately equal across the three groups (0.4%). All patients had a BMI >25 kg/m2. No differences were found in the secondary end points. We found a weak relationship between an increasing serum chromium concentration and improvement of the lipid profile.

CONCLUSIONS—There is no evidence that high-dose chromium treatment is effective in obese Western patients with type 2 diabetes.


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Chromium Has No Benefits for Obese Westerners With Poorly Controlled Type 2 Diabetes




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Copyright © 2006 by the American Diabetes Association.