Diabetes Care
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Diabetes Care 29:1535-1537, 2006
DOI: 10.2337/dc05-1367
© 2006 by the American Diabetes Association
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Pathophysiology/Complications
Original Article

IGF-Binding Protein-1 Levels Are Related to Insulin-Mediated Glucose Disposal and Are a Potential Serum Marker of Insulin Resistance

Betty A. Maddux, BS1, Adelene Chan, BS1, Lawrence J. Mandarino, PHD2, Ira D. Goldfine, MD1 and Elena A. De Filippis, MD2

1 Diabetes Center, Department of Medicine, University of California, San Francisco, California
2 School of Life Science, Arizona State University, Tempe, Arizona

Address correspondence and reprint requests to Betty A. Maddux, University of California, San Francisco, 2200 Post, C415, San Francisco, CA 94143-1616. E-mail: bmaddux{at}itsa.ucsf.edu

OBJECTIVE—IGF-binding protein (IGFBP)-1 is negatively regulated by insulin. We determined whether the measurement of IGFBP-1 in serum is a useful marker of insulin resistance.

RESEARCH DESIGN AND METHODS—Twenty-three subjects underwent a euglycemic insulin clamp. Glucose disposal rates (M) were then correlated with measurements of IGFBP-1, fasting insulin levels, homeostasis model assessment (HOMA), and BMI.

RESULTS—IGFBP-1 levels more strongly correlated with M (R = 0.73) than the other parameters such as BMI or HOMA. The level of this protein decreased in individuals who became more insulin sensitive by exercise training.

CONCLUSIONS—These studies show a strong correlation between insulin sensitivity and the serum levels of IGFBP-1. These studies suggest, therefore, that measurement of this protein may be valuable in identifying those individuals with insulin resistance and those individuals who respond to interventional strategies.

Abbreviations: HOMA, homeostasis model assessment • IGFBP, IGF binding protein


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Copyright © 2006 by the American Diabetes Association.