HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: dc07-1189v1 30/11/2838    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Williams, P. T. Search for Related Content PubMed PubMed Citation Articles by Williams, P. T. Social Bookmarking                What's this?

Changes in Vigorous Physical Activity and Incident Diabetes in Male Runners

From the Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, California

Address correspondence and reprint requests to Paul T. Williams, PhD, Ernest Orlando Lawrence Berkeley National Laboratory, Life Sciences Division, 1 Cyclotron Rd., Berkeley, CA 94720. E-mail: ptwilliams{at}lbl.gov

OBJECTIVE—We examined the relationship between changes in reported vigorous exercise and self-reported physician-diagnosed diabetes in 25,988 active men.

RESEARCH DESIGN AND METHODS—The dose-response relationship between changes in reported vigorous exercise (running distance, change in kilometers per week) and self-reported physician-diagnosed diabetes was followed prospectively for 7.8 ± 1.8 years (means ± SD).

RESULTS—Logistic regression analyses showed that the log odds for diabetes declined significantly in relation to men's change in running distance (coefficient ± SE: –0.012 ± 0.004, P < 0.01), which remained significant when adjusted for BMI (–0.018 ± 0.003, P < 0.0001). The decline in the log odds for diabetes was related to the distance run at the end of follow-up when adjusted for baseline distance, with (–0.024 ± 0.005, P < 0.0001) or without (–0.027 ± 0.005, P < 0.0001) adjustment for BMI. Baseline distance was unrelated to diabetes incidence when adjusted for the distance at the end of follow-up. Compared with men who ran <8 km/week at the end of follow-up, incidence rates in those who ran 8 km/week were 95% lower between 35 and 44 years of age (P < 0.0001), 92% lower between 45 and 54 (P < 0.0001), 87% lower between 55 and 64 (P < 0.0001), and 46% lower between 65 and 75 (P = 0.30). For the subset of 6,208 men who maintained the same running distance during follow-up (±5 km/week), the log odds for diabetes declined with weekly distance run (–0.024 ± 0.010, P = 0.02) but not when adjusted for BMI (–0.005 ± 0.010, P = 0.65).

CONCLUSIONS—Vigorous exercise significantly reduces diabetes incidence, due in part to the prevention of age-related weight gain and in part to other exercise effects.

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?