HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: dc06-2010v1 30/7/1758    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pavkov, M. E. Articles by Nelson, R. G. Search for Related Content PubMed PubMed Citation Articles by Pavkov, M. E. Articles by Nelson, R. G. Social Bookmarking                What's this?

Changing Patterns of Type 2 Diabetes Incidence Among Pima Indians

From the Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona

Address correspondence and reprint requests to Dr. Meda E. Pavkov, National Institutes of Health, 1550 East Indian School Rd., Phoenix, AZ 85014-4972. E-mail: mpavkov{at}phx.niddk.nih.gov

OBJECTIVE— The rising prevalence of obesity and high prevalence of diabetes among Pima Indians suggest that the incidence of diabetes has risen over time. We examined trends in the incidence rate of type 2 diabetes among Pima Indians between 1965 and 2003.

RESEARCH DESIGN AND METHODS— Incidence rates were computed independently in three 13-year time periods in Pima Indians aged 5 years. Diabetes was defined by the presence of at least one of two criteria: 1) 2-h plasma glucose concentration 200 mg/dl (11.1 mmol/l) or 2) hypoglycemic treatment.

RESULTS— Among 8,236 subjects without diabetes at baseline, 1,005 incident cases occurred during follow-up. Age- and sex-adjusted incidence rates of diabetes were 25.3 cases/1,000 patient-years (95% CI 22.5–28.0) in 1965–1977, 22.9 cases/1,000 patient years (20.0–25.8) in 1978–1990, and 23.5 cases/1,000 patient years (20.5–26.5) in 1991–2003 (P = 0.3). The incidence rate in subjects aged 5–14 years was 5.7 (1.9–17.4) times as high in the last as in the first period, but the rate declined in those aged 25–34 years (incidence rate ratio 0.6 [0.4–0.8]). Sex-adjusted prevalence increased significantly over time only in those aged 5–24 years (P_trend < 0.0001).

CONCLUSIONS— The overall incidence of diabetes among Pima Indians remained stable over the past four decades, with a significant rise occurring only in the youth.

Abbreviations: OGTT, oral glucose tolerance test

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				J. Krakoff, L. Ma, S. Kobes, W. C. Knowler, R. L. Hanson, C. Bogardus, and L. J. Baier Lower Metabolic Rate in Individuals Heterozygous for Either a Frameshift or a Functional Missense MC4R Variant Diabetes, December 1, 2008; 57(12): 3267 - 3272. [Abstract] [Full Text] [PDF]

				J. M. Lee Why Young Adults Hold the Key to Assessing the Obesity Epidemic in Children Arch Pediatr Adolesc Med, July 1, 2008; 162(7): 682 - 687. [Abstract] [Full Text] [PDF]