HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: dc06-2461v1 30/9/2258    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Valdés, S. Articles by Cadórniga, F. D. Search for Related Content PubMed PubMed Citation Articles by Valdés, S. Articles by Cadórniga, F. D. Social Bookmarking                What's this?

Population-Based Incidence of Type 2 Diabetes in Northern Spain

The Asturias Study

¹ Endocrinology and Nutrition, Hospital Central de Asturias, Oviedo, Spain
² Endocrinology and Nutrition, Hospital Carlos Haya, Málaga, Spain
³ Medicine, Hospital San Agustín, Avilés, Spain
⁴ Clinical Biochemistry, Hospital Central de Asturias, Oviedo, Spain

Address correspondence and reprint requests to Dr. Sergio Valdés, Endocrinology and Nutrition, Hospital Carlos Haya, Plaza del Hospital Civil, 29009 Málaga, Spain. E-mail: sergiovaldes{at}vodafone.es

OBJECTIVE—The aim of this study was to define the incidence of type 2 diabetes in a low-risk Caucasian population in northern Spain and its association with various risk factors.

RESEARCH DESIGN AND METHODS—The Asturias Study is a prospective, population-based survey of diabetes and cardiovascular risk factors. The baseline examination was carried out during 1998–1999 when 1,034 individuals, aged 30–75 years, were randomly selected to determine the prevalence of type 2 diabetes and pre-diabetes in the Principality of Asturias (northern Spain). In 2004–2005, these same subjects were invited for a follow-up examination; 700 participated. This study includes only those individuals who did not have diabetes at baseline. We used the World Health Organization 1999 criteria to classify glucose metabolism at both baseline and follow-up.

RESULTS—The incidence of diabetes adjusted for the age and sex structure of Asturias was 10.8 cases/1,000 person-years (95% CI 8.1–14.8). The incidence rates were 5 cases/1,000 person-years in individuals with normoglycemia, 21 cases/1,000 person-years in individuals with isolated impaired glucose tolerance (IGT), 34.7 cases/1,000 person-years in individuals with isolated impaired fasting glucose (IFG), and 95.2 cases/1,000 person-years in individuals with combined IFG-IGT. Stepwise multiple logistic regression analysis showed that, together with fasting plasma glucose (FPG) and 2-h plasma glucose, which were the strongest predictors of diabetes, triglycerides and BMI were also independently associated with progression to diabetes.

CONCLUSIONS—In this 6-year prospective population-based study, we found an incidence of type 2 diabetes of 10.8 cases/1,000 person-years. Both FPG and 2-h plasma glucose were strongly predictive of diabetes, and their effect was additive.

Abbreviations: FPG, fasting plasma glucose • IFG, impaired fasting glucose • IGT, impaired glucose tolerance • OGTT, oral glucose tolerance test

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?