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Coffee Consumption Is Associated With Higher Plasma Adiponectin Concentrations in Women With or Without Type 2 Diabetes

A prospective cohort study

¹ Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts
² Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts
³ Channing Laboratory, Brigham and Women's Hospital, Boston, Massachusetts
⁴ Department of Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts
⁵ Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts

Address correspondence and reprint requests to Christos Mantzoros, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215. E-mail: cmantzor{at}bidmc.harvard.edu

To test whether the beneficial effects of coffee consumption in metabolism might be explained by changes in circulating levels of adiponectin, we evaluated self-reported habitual coffee and tea consumption and caffeine intake as predictors of plasma adiponectin concentrations among 982 diabetic and 1,058 nondiabetic women without cardiovascular disease from the Nurses' Health Study. Women with and without diabetes who drank 4 cups of coffee per day had significantly higher adiponectin concentrations than those who didn't drink coffee regularly (7.7 vs. 6.1 µg/ml, respectively, in diabetic women, P = 0.004; 15.0 vs. 13.2 µg/ml in nondiabetic women, P = 0.04). Similar associations were observed for caffeine intake. We confirm previously reported inverse associations of coffee consumption with inflammatory markers, C-reactive protein, and tumor necrosis factor- receptor II. Adjustment for adiponectin did not weaken these associations, and adjustment for inflammatory markers did not attenuate the association between coffee consumption and adiponectin concentrations. High consumption of caffeine-containing coffee is associated with higher adiponectin and lower inflammatory marker concentrations.

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				K. Kotani, S. Fujiwara, T. Hamada, K. Tsuzaki, and N. Sakane Coffee Consumption Is Associated With Higher Plasma Adiponectin Concentrations in Women With or Without Type 2 Diabetes: Response to Williams et al. Diabetes Care, May 1, 2008; 31(5): e46 - e46. [Full Text] [PDF]

				R. M. van Dam, F. B. Hu, and C. S. Mantzoros Coffee Consumption Is Associated With Higher Plasma Adiponectin Concentrations in Women With or Without Type 2 Diabetes: Response to Kotani et al. Diabetes Care, May 1, 2008; 31(5): e47 - e47. [Full Text] [PDF]