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Possible Role of Oxidative Stress in the Pathogenesis of Hypertension

From the Centre of Excellence in Diabetes and Endocrinology, University Hospital of Coventry and Warwickshire, Warwick Medical School, University of Warwick, Coventry, U.K

Address correspondence and reprint requests to Prof. Antonio Ceriello, Warwick Medical School, Clinical Science Research Institute, Clinical Science Building, University Hospital–Walsgrave Campus, Clifford Bridge Rd., Coventry CV2 2DX, U.K. E-mail: antonio.ceriello{at}warwick.ac.uk

Recently oxidative stress has been proposed as the cause of hypertension. An imbalance in superoxide and nitric oxide production may account for reduced vasodilation, which in turn can favor the development of hypertension. In vitro and in human studies support this hypothesis. The supplementation of antioxidants, particularly in the form of fresh fruit and vegetables, reduces blood pressure, supporting a role for free radicals in hypertension.

Abbreviations: DASH, Dietary Approaches to Stop Hypertension • ROS, reactive oxygen species • RVD, renovascular disease

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