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Diabetes Care, Vol 9, Issue 1 53-56, Copyright © 1986 by American Diabetes Association

ARTICLES

Abnormalities in insulin secretion in healthy offspring of Indian patients with maturity-onset diabetes of the young

V Mohan, C Snehalatha, A Ramachandran and M Viswanathan

Serum C-peptide (CP) and immunoreactive insulin (IRI) responses were studied in 47 euglycemic offspring of patients with maturity-onset diabetes of the young (MODY). Mean IRI responses were not significantly different in nonobese offspring of MODY patients (O-MODY) but they were lower in obese O-MODY than in respective controls. Mean CP responses were low in both groups, the change being more pronounced in obese O-MODY. These findings indicate that alterations of secretion and metabolism of insulin can be detected even before glucose intolerance is seen in O-MODY.
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C. R. Scott, J. M. Smith, M. M. Cradock, and C. Pihoker
Characteristics of Youth-onset Noninsulin-dependent Diabetes Mellitus and Insulin-dependent Diabetes Mellitus at Diagnosis
Pediatrics, July 1, 1997; 100(1): 84 - 91.
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Copyright © 1986 by the American Diabetes Association.