Diabetes Care
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Diabetes Care Publish Ahead of Print published online ahead of print April 16, 2008
DOI: 10.2337/dc08-0116
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dc08-0116v1
31/7/1445    most recent
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Hannon, T. S.
Right arrow Articles by Arslanian, S. A.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hannon, T. S.
Right arrow Articles by Arslanian, S. A.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Original Research

Hyperinsulinemia in African American (AA) Adolescents Compared with Their American White (AW) Peers Despite Similar Insulin Sensitivity: A Reflection of Up-Regulated β-Cell Function?

Tamara S. Hannon, M.D.1, Fida Bacha, M.D.1, Yan Lin, Ph.D.2 and Silva A. Arslanian, M.D.1

1Division of Pediatric Endocrinology, Metabolism, and Diabetes, Children's Hospital of Pittsburgh, Pittsburgh, PA 15213
2Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA 15213

tamara.hannon{at}chp.edu

ABSTRACT

Objective: African American (AA) children are hyperinsulinemic and insulin resistant compared with American White (AW) children. Previously, we demonstrated that insulin secretion relative to insulin sensitivity was ~75% higher in AA compared with AW children, suggesting that hyperinsulinemia in AA children is not merely a compensatory response to lower insulin sensitivity. The aim of the present investigation was to assess if glucose-stimulated insulin response is higher in AA vs AW adolescents who have comparable in vivo insulin sensitivity.

Methods: The hyperinsulinemic-euglycemic and hyperglycemic clamp techniques were utilized to assess first and second phase insulin secretion. Insulin secretion relative to insulin sensitivity was calculated as the glucose disposition index.

Results: AA adolescents compared with their AW peers with comparable insulin sensitivity and body composition had higher first-phase insulin concentrations.

Conclusion: The quantitative relationship between insulin sensitivity and first phase insulin appears to differ among AA and AW adolescents.


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2008 by the American Diabetes Association.