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Diabetes Care Publish Ahead of Print published online ahead of print May 5, 2008
DOI: 10.2337/dc08-0621
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Original Research

Dysglycemia and a history of reproductive risk factors

Sarah D. McDonald, MD, MSc1, Salim Yusuf, MD, DPhil2,,3,,4, Patrick Sheridan, MSc4, Sonia S. Anand, MD, PhD2,,4 and Hertzel C. Gerstein, MD, MSc2,,4,,5

1Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
2Department of Medicine, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
3Division of Cardiology
4Population Health Research Institute
5Division of Endocrinology and Metabolism

mcdonals{at}mcmaster.ca

ABSTRACT

Objective: To identify reproductive risk factors associated with dysglycemia (diabetes, impaired glucose tolerance, and impaired fasting glucose) in a contemporary, multiethnic population.

Research Design and Methods Study Design: We studied 14,661 women screened with an OGTT for the DREAM Trial. Reproductive risk factors were compared in normoglycemic and dysglycemic women.

Results: Dysglycemia was significantly associated with the number of children born (OR 1.03 per child, 95% CI 1.01-1.05), age (OR 1.05 per year, 1.04-1.05), non-European ancestry (OR 1.09, 1.01-1.17), pre-eclampsia/eclampsia (OR 1.14, 1.02-1.27), irregular periods (OR 1.21, 1.07-1.36), and GDM (OR 1.53, 1.35-1.74). The relationship between GDM and dysglycemia did not differ across BMI tertiles (p=0.84), nor did the relationships of other risk factors.

Conclusions: Reproductive factors, particularly GDM, are associated with dysglycemia in middle-aged women from many ethnicities. Reproductive factors can be used to counsel young women about their future risk of dysglycemia, while in middle age they may help screen for dysglycemia.


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