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Caffeine Increases Ambulatory Glucose and Postprandial Responses in Coffee Drinkers With Type 2 Diabetes

Duke University Medical Center, Durham, North Carolina

Address correspondence and reprint requests to James D. Lane, PhD, Box 3830, Duke University Medical Center, Durham, NC 27710-0001. E-mail: james.lane@duke.edu

Abbreviations: CGMS, continuous glucose monitoring system

The first 20% of the full text of this article appears below.

	INTRODUCTION

 
Recent laboratory studies demonstrated that caffeine exaggerates glucose and insulin responses to standardized carbohydrate loads in habitual coffee drinkers who have type 2 diabetes (1–3). Similar postprandial effects in everyday life could disrupt clinical efforts to maintain glucose control in patients with type 2 diabetes. The aim of this study was to examine the effects of a moderate dose of caffeine on glucose levels and postprandial glucose responses in free-living coffee drinkers with type 2 diabetes. We specifically predicted that caffeine administration would increase glucose concentrations during the day and exaggerate the glucose increases that followed meals when habitual coffee drinkers with type 2 diabetes were monitored during everyday life.

	RESEARCH DESIGN AND METHODS—

 
The research protocol, approved by the Duke University Health Systems institutional review board, employed a double-blind crossover design to compare the effects of a moderate dose of caffeine (500 mg/day) with that of a placebo control. Subjects completed informed consent before testing and received $150.00 in compensation. The study group included 10 habitual coffee drinkers (five men and five women) who drank brewed coffee daily. All had at least a 6-month history of type 2 diabetes managed by a stable regimen of diet, exercise, and oral agents but no exogenous insulin. Subjects were free of major medical disorders, were nonsmokers, and . . . [Full Text of this Article]

	RESULTS—

 

	CONCLUSIONS—

 

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