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Diabetes Care 31:e32 2008
DOI: 10.2337/dc08-0047
© 2008 by the American Diabetes Association
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Online Letters: Observations

Early Subclinical Atherosclerosis in Women With Previous Gestational Diabetes Mellitus

Laura Volpe, MD1, Ilaria Cuccuru, MD1, Cristina Lencioni, MD1, Vinicio Napoli, MD2, Alessandra Ghio, MD1, Carmen Fotino, PHS1, Alessandra Bertolotto, MD1, Giuseppe Penno, MD1, Luca Benzi, MD1, Stefano Del Prato, MD1 and Graziano Di Cianni, MD1

1 Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
2 Department of Radiology, University of Pisa, Pisa, Italy

Corresponding author: Dr. Graziano Di Cianni, Endocrinology and Metabolism, Ospedale di Cisanello, Via Paradisa, 2, I-56126 Pisa, Italy. E-mail: dicianni@immr.med.unipi.it

The first 20% of the full text of this article appears below.

To determine if women with previous gestational diabetes mellitus (pGDM), a population at high risk for type 2 diabetes and metabolic syndrome (1), have signs of subclinical atherosclerosis, we measured carotid intimal-medial thickness (IMT) and multiple cardiovascular risk factors in 28 women with and 24 without pGDM (control group) 2 years after delivery. A 75-g 2-h oral glucose tolerance test was performed for assessment of glucose tolerance, area under the glucose curve (AUCgluc), insulin sensitivity index, homeostasis model assessment of insulin resistance (HOMA-IR), lipid profile, oxidized LDL (oxLDL), C-reactive protein (CRP), adiponectin, and fibrinogen. Family history, anthropometric parameters, and blood pressure were recorded. IMT was measured at four . . . [Full Text of this Article]


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Copyright © 2008 by the American Diabetes Association.